Normal TSH Levels: What’s Normal & Why?

Introduction

Thyroid hormones are extremely important for our health.

In fact, abnormal thyroid levels have serious consequences to a child's growth and development.

Hypothyroidism and hyperthyroidism are common disorders resulting from abnormal thyroid-stimulating hormone (also called thyrotropin).

The risk of thyroid disorders during our lifetime is quite high. It increases with age and senior population is most affected.

A study from Denmark suggests overall risk of overt (i.e., clinical stage) hypothyroidism or hyperthyroidism diagnosis, during a person's lifetime, is close to 10% (Carle’ 2006).

The risk for women is even higher. At almost 15% it's almost five-times higher than men.

For US, Europe, and other developed countries, where iodine deficiency is rare, the risk is comparable.

Regularly testing thyroid levels is one way to reduce this risk.

Epidemiology of sub-types of hypothyroidism in Denmark by Allan Carlé and others in European Journal of Endocrinology, vol. 154 (1), 2006.

What are normal TSH levels?

The chart below shows ranges for optimal TSH levels. It also includes the lab ranges for other key thyroid hormones and TPO antibodies-a marker of immune response against the thyroid gland.

Normal range for TSH, free T3, free T4 and TPO antibodies for one of our at-home thyroid test.

The distribution of Thyroid Stimulating Hormone in healthy population is close to a bell curve (but it is asymmetric, i.e., non-Gaussian distribution). The curve skews to the right—high TSH levels seem to be more common than low levels.

Healthy values lie between 0.1 mIU/L and 4.5 mIU/L.

Statistically, that's between 2.5th and 97.5th percentile (±3 standard deviation). Which means 95% of the people have thyroid levels in this range.

Age, gender, race, and iodine consumption can cause variations.

The plot below shows data from a study of 1,671 healthy Danish women.

Lower prevalence of mild hyperthyroidism related to a higher iodine intake in the population: prospective study of a mandatory iodization programme by Vejbjerg & others, in Clinical Endocrinology, Vol 71 (3) 2009.

What are the reasons for high Thyroid Stimulating Hormone levels?

Problems with the hypothalamus, pituitary, or thyroid gland can cause abnormal TSH levels.

Here are few other common factors that play a role:

• Sleep
• Pregnancy
• Illness
• Medication
• Age

How sleep affects TSH levels?

• The 24-hour trend below shows Thyroid Stimulating Hormones vary in two different cyclical patterns (Weeke and Gundersen 1978). T3—and even T4 to a less extent—follows similar trend.
• During the night while sleeping, TSH increases by almost 150% in comparison to day time. As we wake up, it decreases slowly. Therefore, results can vary appreciably depending on the time of sample collection. This trend over 24 hour is called diurnal or daily rhythm.
• The pituitary gland in our brain releases this hormone in short pulses. The levels rise by about 10-15% every 30 minutes resulting in a pulsating trend. A close inspection shows the peaks of pulses are higher during sleep in comparison to day time.
• Insufficient sleep may disrupt this natural rhythm, causing in higher than optimal levels in the morning.
• That's why night shift employees and those with abnormal circadian rhythm may observe unexpected results from their TSH blood tests.

Circadian and 30 Minutes Variations in Serum TSH and Thyroid Hormones in Normal Subjects by Weeke and Gundersen in Acta Endocrinol (Copenh), 1978, Vol. 89(4), pages 659‐672.

How pregnancy affects Thyroid Stimulating Hormone?

• The pregnancy hormone, hCG, human chorio-gonadotropin, weakly stimulates the thyroid, as hCG is structurally similar to TSH.
• Both of them drop together, especially in very early stage of pregnancy.
• Therefore, trimester specific ranges of thyroid hormones should be used by labs to test pregnant women (Laurberg 2011).
• Optimal TSH levels are critically important for a baby's development and normal pregnancy.

The plot below shows mother’s hormone levels by week of pregnancy:

Thyroid disease in pregnancy: new insights in diagnosis and clinical management by Korevaar and others in Nature Reviews Endocrinology, 2017, Vol. 13, pages 610–622.

How illness and medication affect Thyroid Stimulating Hormone?

• Illness may affect functions of hypothalamus, pituitary and thyroid glands. This may result in low levels.
• Medication for certain illnesses might affect the thyroid function.
• During recovery from illness, levels might temporarily spike as thyroid stabilizes.
• Obesity and overfeeding increases pituitary and thyroid function. This may result in higher levels (Laurberg 2011).
• Always ask the lab for normal range of your test. This is the range you should monitor since values vary as part of the normal sample processing.

How age affects Thyroid Stimulating Hormone?

• TSH rises with age. And the correlation is almost linear (Hollowell 2002).
• The risk of thyroid problems among 80+ year old is almost 5-times those below 50. This holds despite gender, race, and geography affecting the gland.
• In almost every age group, women tend to have higher values than men.
• The risk of abnormal levels is highest in older women and lowest among most men.

Thyroid Stimulating Hormone levels continuously increase with age.

National Health and Nutrition Examination Survey (NHANES III): Serum TSH, T4, and Thyroid Antibodies in the United States Population (1988 to 1994) by Hollowell and others in The Journal of Clinical Endocrinology & Metabolism, Vol. 87(2) 1 February 2002, Pages 489–499.

What happens if your TSH values are high?

• High values are likely sign of an underactive thyroid gland. It is forcing the pituitary gland to release more hormone, a condition known as hypothyroidism.
• Values over 10 mIU/L is overt or clinical hypothyroidism. Studies show it results in higher levels of cholesterol—both total and low-density cholesterol (Mason 1930).
• Mildly elevated values (above 4.5 mIU/L) are a known risk factor for future overt hypothyroidism.
• The slow increase in Thyroid Stimulating Hormone with age is unharmful and might, in fact, help in longer life despite some risk of cardiovascular disease (Atzmon 2009, Rozing 2010, Gussekloo 2004).

What happens if TSH values are low?

• Low values are indication of hyperthyroidism. It is likely sign of an overactive thyroid gland that is producing high levels of thyroid hormones, T4 and T3 (Pantalone and Nasr 2010).
• Abnormally low (less than 0.1 mIU/L) values are almost always an indication of overt (or clinical) hyperthyroidism (Helfand 2004).
• Elevated T4 and T3 with abnormally low values may indicate nodular thyroid disease or an autoimmune Grave’s disease.
• There is good evidence that undetectable low values (less than 0.1 mIU/L) increase the risk of atrial fibrillation later in life (Helfand 2004). These correlate with higher probability of stroke. In one study of those older than 60 years, the risk of atrial fibrillation over 10 years was around 32%. In comparison, the risk is 8% in people with healthy levels (Sawin 1994).
• Some studies suggest low hormone results in loss of bone mineral density and bone fracture. However, this seems true only for vertebral fracture. Data do not suggest any correlation to hip fracture (Helfand 2004).
• Low values (0.1 – 0.4 mIU/L) should always follow a measurement of T4 and T3, according to recommendations from theCleveland Clinic Journal of Medicine. They should be rechecked within few weeks to confirm the results and to avoid potential variation due to a one-off event.

What are the symptoms of high Thyroid Stimulating Hormone?

Well known symptoms of high values include:

• Intolerance to cold (compared to those around you)
• Weight gain
• Loss of appetite
• Low energy and weakness
• Coarse dry hair
• Dry rough skin
• Fatigue (which can happen with both low and high values)

What are the symptoms of low Thyroid Stimulating Hormone?

Common symptoms of low levels include:

• Intolerance to heat (compared to those around you)
• Palpitations
• Anxiety
• Tremors
• Difficulty in sleeping or insomnia
• Unusually high appetite and weight loss
• Fatigue (which can happen with both low and high TSH)

How Thyroid Stimulating Hormone affects weight loss and BMI?

Samples from Framingham Heart Study show a linear correlation between gain in weight and high TSH values. The data suggest women show larger weight gain.

Correlation of Thyroid Function to Body Weight – Cross-sectional and Longitudinal Observations in a Community-Based Sample by Caroline Fox and others in Archives of Internal Medicine, Vol 168 (6), MAR 24, 2008.

Another chart below shows an average weight gain after 6-months of testing. Weight increases almost linearly with higher values. Similar gains have been reported after 5 years, except for those with values above 3.6 mU/L. They gained over 10 lbs!

Small Differences in Thyroid Function May Be Important for Body Mass Index and the Occurrence of Obesity in the Population by Nils Knudsen and others in The Journal of Clinical Endocrinology & Metabolism, Volume 90 (7), July 2005, Pages 4019–4024.

Why a TSH blood test alone is not enough?

Thyroid health is determined by the hypothalamus-pituitary-thyroid (HPT) axis. One gland often tends to compensate for abnormal behavior of another to maintain a balanced cycle.

Whenever thyroid cannot release sufficient T4, the pituitary compensates additional TSH. Therefore, knowing TSH alone might not be sufficient for a full diagnosis.

There is a well known linear correlation between age and Thyroid Stimulating Hormone. However, T4 values do not show any correlation with age. Therefore, with advancing age, there is a lower pituitary response to thyroid function which a TSH test alone might not capture.

If TSH values are abnormal, one should check T4 and T3 for thyroid dysfunction. Also, checking for TPO antibodies can help assess the presence of autoimmune thyroid disease (Glinoer and Spencer 2010).

Autoimmune diseases–and presence of TPO antibodies–in certain groups can be very high, e.g., elderly white women have a rate of almost 50% positivity (Laurberg 2011). Those aged 55+ years with TSH above 4.5 mIU/L have a rate of 36-76% (Boelaert 2013).

In some cases, e.g., during pregnancy, a combination of thyroid dysfunction and high TPO antibodies may predict complications in pregnancy and mother's risk of dying later in life (Männistö 2010).

What to know about repeat testing?

• If your levels are outside normal range, a repeat test is very useful. In one study, repeat of 400,000 patients after 5 years suggested that only 2% had developed abnormal levels. And 50% were within healthy levels (Meyerovitch 2007).
• How do you know whether a high value was not a random event? Analytical studies suggest a deviation of 40% or higher, from last measurement, is not a random event (Karmisholt 2010).
• Mean values of healthy Thyroid Stimulating Hormone in a person are mostly determined by their genetics. However, environmental factors can affect them considerably (e.g., iodine content in food).
• The variation is much narrower for individual person in comparison to population variation. There is about 50% tighter variation in comparison to data for large population.
• TSH is the most sensitive indicator of thyroid gland function when pituitary-hypothalamus function is healthy. For example, a thirty percent reduction in T4 results in a sixfold increase in TSH (Eisenberg 2009).