Certain genes increase the risk of cognitive and cardiovascular decline as we age.
Using a saliva swab, the APOE and MTHFR genetic test checks for genes associated with the risk of developing Alzheimer's, memory loss, early onset of dementia, and cardiovascular disease.
Our Home MTHFR and Alzheimer’s At-Home Test is easy, fast, reliable, and requires just a few steps:
Order Online.
Receive The Kit And Collect Sample At Home.
Ship It Back For FREE To Our World-Class CLIA Labs (US only).
Receive Secure, Confidential, & Easy-To-Understand Report Within Days For Your Comprehensive Home MTHFR and Alzheimer’s At-Home Test.
APOE (apo-lipo-protein E) gene is associated with inheriting an increased risk of Alzheimer's disease, dementia and cardiovascular diseases. After cardiovascular disease and cancer, Alzheimer's is the third largest cause of death in America.
Everyone has two copies of APOE genes (one from each parent) and occur as E2, E3, and E4. The E4 version is associated with degenerate diseases such as dementia and Alzheimer's. It has also been shown to increase chance of atherosclerosis, a plaque responsible for artery blockage. The E2 version has been shown to increase the risk of certain rare cardiovascular diseases.
MTHFR (methyele-tetra-hydro-folate reductase) is a gene responsible for helping our bodies make proteins.
It is specifically important to digest folate or vitamin B9, and helps regulate homocysteine levels.
The APOE and MTHFR Genetic Test is an at-home genetic test that checks for APOE genotype. The test uses a saliva swab for sample collection.
The APOE gene is a major genetic risk factor for early stage neuro-de-generative disease. Studies show that people carrying the E4 allele pair have a higher prevalence of Alzheimer's disease (at 91%) and much lower mean age of onset (at around 68 years of age). In comparison, for those carrying E2 pair, studies show the prevalence to be around 20% and mean age at onset approximately 84 years.
The MTHFR gene is important for digesting vitamin B9, and for reducing homo-cysteine in blood. It is also important in the metabolism of metho-trex-ate, a drug used in rheumatoid arthritis and chemotherapy.
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You can order an simple, low-cost genetic test to assess your risk of cognitive decline without going to a doctor or lab. Order the test kit online, collect a saliva sample with few swabs, send the sample to our CLIA-certified labs, and find out your risk of Alzheimer's disease and dementia in few days.
Our thoroughly researched articles are easy to read and review the latest research in the field. Go deeper with data-driven information on some of the most common tests and the up-to-date research. You can read them anytime from the menu at the top.
Stay on top for the latest news and research by following the Alzheimer's Association. Also, you can learn more about APOE and MTHFR at the NIH Genetics Home Reference.
A: Except New York and New Jersey our tests are available in all 48 states. State regulations in NY, NJ do not allow us to ship the tests to their residents.
A: The kit for our APOE and MTHFR Genetic Test contains few saliva swabs, instructions on how to collect the sample, and a form requesting basic information including date and time of collection. The directions are straight forward and easy to follow.
A: You will receive the kit within 3-5 business days with a prepaid return envelope. After you ship the sample and it is received by our lab, you receive the results within 5-7 business days.
A: Your samples are kept by the lab for two weeks and the extracted DNA is kept for 3 months. The samples are disposed off in biohazardous waste that is picked up by a certified waste management company that specializes in medical waste disposal and follows strict regulatory guidelines.
Regarding your data: we are required to maintain the data for a minimum of 2 years. Your data is released only to those authorized by you. We also ensure that such information is maintained in the strictest confidence in accordance with HIPAA and other applicable federal and state laws and regulations. In certain cases, we may release information to a third party if such information is required for medical treatment or by federal or state law.
A: The report with your test results will be easy to understand and will have all the necessary details. It will mark your genotype for Alzheimer's and Cardiovascular diseases. It will briefly discuss what the results mean.
A: No. We do not have the capability to process the insurance claim. Insurance plans vary by individuals and may not pay for genetic testing. Please talk to your insurance provider if you have any further concerns.
A: We have partnered with CLIA-certified labs that are used by physicians across the US. These labs are regulated by the states, as well as Centers for Medicare and Medicaid Services (CMS). Majority of the tests from these labs are FDA approved to ensure they meet the proper regulatory requirements. Additionally, the College of American Pathologists (CAP) requires inter-laboratory tests to ensure the ranges established by each lab do not drift or are not out of acceptable ranges. This is done by regularly testing reference samples between different labs. Finally, the labs test thousands of sample for different age groups and health conditions, and have well established reference data to compare your results against this large pool.
A: Unfortunately, no. As a lab test provider we can only test and report out data from your samples. We are not authorized to provide any medical recommendations. But we strongly encourage you to discuss the results with your doctor for next steps.
Reasons to order an APOE & MTHFR Genetic Risk test kit from RxHomeTest.com:
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