Apo-lipo-protein-E genes help in converting fats into cholesterol. They play key role in cognitive and heart health after a certain age.
NEW! The test also includes KLOTHO (KL) genes, another marker of aging. KLOTHO is known to play key roles in dementia as well as in Alzheimer's, multiple sclerosis, and Parkinson's disease.
Using simple and easy-to-use saliva swabs, the APOE genetic test checks for gene markers APOE E2, E3, and E4 that are associated with the risk of developing Alzheimer's, dementia, and cardiovascular disease.
Our Home APOE Genetic Test is easy, fast, reliable, and requires just a few steps:
Order Online.
Receive The Kit And Collect Sample At Home.
Ship It Back For FREE To Our World-Class CLIA Labs (US only).
Receive Secure, Confidential, & Easy-To-Understand Report Within Days For Your Comprehensive Home APOE Genetic Test.
APOE (apolipoprotein E) gene is associated with inheriting an increased risk of Alzheimer's disease, dementia and cardiovascular diseases.
Alzheimer's is the third largest cause of death in America, after cardiovascular disease and cancer.
Everyone has two copies of APOE genes (one from each parent) as E2, E3, and E4.
The E4 version is associated with degenerative diseases such as dementia and Alzheimer's.
It has also been shown to increase chances of atherosclerosis, a plaque responsible for artery blockage.
The E2 version has been shown to increase the risk of certain rare cardiovascular diseases.
The APOE Test is an at-home genetic test that checks for APOE genotype. The test uses a saliva swab for sample collection.
The amplified nucleotides sites for the APOE test are: Apolipoprotein E, T471C rs429358, C609T rs7412.
Although APOE is the strongest marker or Alzheimer's, a new gene on chromosome 13 called KLOTHO has neuroprotective and anti-aging properties.
It makes a protein of the same name that affects aging process.
Levels of KLOTHO protein decline with age. But certain variations are shown to have neuroprotective, anti-cell damage, and antioxidant properties.
The most common effect of this decline is neurodegeneration which causes dementia and related disorders such as Alzheimer's Parkinson's and Multiple Sclerosis.
However, certain variations can reduce neuron damage that causes cognitive decline and shortens life span.
Thus, they help preserve the structure of neurons in the brain to help reduce the aging process.
KLOTHO has also other important roles in kidney health, Vitamin D metabolism, cardiovascular diseases, musculoskeletal disorders, skin diseases, and cancer development.
The three forms: alpha, beta and gamma KLOTHO have different roles in various organs but the anti-aging aspect mostly related to alpha-KLOTHO.
Please note: sometimes your sample may not give any results due to insufficient material on the swab.
The word KLOTHO comes from Greek mythology and is named after one of Zeus's three daughters who spin (Klotho), measure (Lechesis), and cut (Atropos) the thread of life.
Depending on the gene pair, your risk of developing Alzheimer's can vary significantly.
The charts below show the frequency at which Alzheimer's is observed and the age at which it starts strongly depend on how may copies of APOE4 genes one is carrying.
The APOE gene is a major genetic risk factor for early stage neurodegenerative disease.
Studies show that people carrying the E4 allele pair have a higher prevalence of Alzheimer's disease (at 91%) and much lower mean age of onset (at 68 years of age).
In contrast, for those carrying E2 pair, the rate is approximately 20% and mean age at onset around 84 years.
It seems higher meat consumption might reduce the risk of Alzheimer's.
A recent Swedish study of 2157 adults without dementia suggests 'higher total meat consumption was associated with slower cognitive decline and a reduced dementia risk among older adults with APOE ε3/ε4 and ε4/ε4 genotypes'.
See this NEJM video on different stages of Alzheimer's and managing them.
Read our detailed reports on:
Live Long and Prosper: Longevity, Alzheimer’s, and Role of APoE
How CRP Affects the Heart: CRP, Inflammation, and Risk of Heart Disease
You can order an easy, low-cost genetic test to assess your risk of cognitive decline without going to a doctor or lab:
(1) Order a test kit online; (2) collect saliva with few swabs; (3) send the sample to our CLIA-certified labs; and (4) find out your risk of Alzheimer's disease and dementia in few days.
Our thoroughly researched articles are easy to read and review latest research in the field. Go deeper with data-driven information on some of the most common tests and up-to-date research. You can read them anytime from the menu at the top.
Stay on top for the latest news and research by following the Alzheimer's Association. Learn more about APOE at the NIH Genetics Home Reference.
A: Except New York and New Jersey our tests are available in all 48 states. State regulations in NY, NJ, do not allow us to ship the tests to their residents.
A: The kit for our APOE & KLOTHO Genetic Test contains: (1) few saliva swabs, (2) instructions on how to collect the sample, and (3) a form requesting basic information including date and time of collection. The directions are straight forward and easy to follow.
A: You will receive the kit within 3-5 business days with a prepaid return envelope. After you ship the sample and it is received by our lab, you receive the results within 5-7 business days.
A: Your samples are kept by the lab for two weeks and the extracted DNA is kept for 3 months. The samples are disposed off in biohazardous waste that is picked up by a certified waste management company that specializes in medical waste disposal and follows strict regulatory guidelines.
Regarding your data: we are required to maintain the data for a minimum of 2 years. Your data is released only to those authorized by you. We also ensure that such information is maintained in the strictest confidence in accordance with HIPAA and other applicable federal and state laws and regulations. In certain cases, we may release information to a third party if such information is required for medical treatment or by federal or state law.
A: The report with your test results will be easy to understand and will have all the necessary details. It will mark your genotype for Alzheimer's and Cardiovascular diseases. It will briefly discuss what the results mean.
A: No. We do not have the capability to process the insurance claim. Insurance plans vary by individuals and may not pay for genetic testing. Please talk to your insurance provider if you have any further concerns.
A: We have partnered with CLIA-certified labs that are used by physicians across the US. These labs are regulated by the states, as well as Centers for Medicare and Medicaid Services (CMS). Majority of the tests from these labs are FDA approved to ensure they meet the proper regulatory requirements. Additionally, the College of American Pathologists (CAP) requires inter-laboratory tests to ensure the ranges established by each lab do not drift or are not out of acceptable ranges. This is done by regularly testing reference samples between different labs. Finally, the labs test thousands of sample for different age groups and health conditions, and have well established reference data to compare your results against this large pool.
A: Unfortunately, no. As a lab test provider we can only test and report out data from your samples. We are not authorized to provide any medical recommendations. But we strongly encourage you to discuss the results with your doctor for next steps.
An at-home APOE genetic test ordered online from your home can help check your risk of cognitive decline as well as cardiovascular diseases.
APOE genetic test from RxHomeTest.com help understand the potential future risks of dementia and cardiovascular diseases. The test now includes KLOTHO, another strong marker of anti-aging.
Those with E4 version of APOE inherit an increased risk of developing early-onset of Alzheimer's disease and can be checked with the APOE test.
Our test can help you assess your genetic risk factors for cognitive decline, Alzheimer's disease, and cardiovascular diseases right from the comfort of your home.
Better health results in better quality of life, and a single at-home APOE genetic test from RxHomeTest.com can offer insight not only into various health symptoms, but it can serve as a motivation to treat each of these symptoms and have a better quality of life!
Reasons to order an APOE Genetic Risk test kit from RxHomeTest.com:
Still wondering where to get an APOE Genetic test?
