This powerful endocrine profile test includes a dried urine test and a 6-point saliva test.
Such a combination provides a 360° view of the body's endocrine function, metabolic resilience, as well as insights into endocrine disruptors and organic acids.
The detailed 6-point salivary Cortisol Awakening Response (CAR) assessment offers unique insights into the body's stress response and circadian rhythms.
Using four simple, easy-to-collect urine strips and six saliva tubes, our Endosight dry urine test measures 104 markers and ratios, including body's natural diurnal rhythm and early morning spike.
Our Dry Urine Endocrine Insight Test is easy, fast, reliable, and requires just a few steps:
Order A Dry Urine Test Kit Online.
Receive Your Dried Urine Test Kit and Collect Sample at Home.
Ship It Back For FREE To Our World-Class CLIA Labs (FREE return shipping within US).
Receive Secure, Confidential, & Easy-To-Understand Report Within Days For Your Comprehensive EndoSight+ Dry Urine Test.
It is a combination of two different panels to give you a more comprehensive picture of your health.
First part includes dried urine test (similar to a Dutch® test), collected four times during the day.
It measures key hormones includes cortisol, several different estrogens and their metabolites, progesterone and its metabolites, endocrine disruptors (e.g., BPA, PFAS, lead, arsenic, cadmium, etc.), androgens (such as testosterone, DHEA), and several key organic acids.
The second part includes six saliva tubes, three of them are collected after waking up, and remaining at noon, evening and night.
This helps generate the cortisol awakening response (CAR) profile, which involves a sharp rise in morning cortisol levels within first hour of waking up.
The remaining samples are used to assess the circadian rhythm of the body, as cortisol levels drop throughout the day.
Here's the list of markers tested:
I. From SALIVA sample:
Cortisol (on waking up)
Cortisol (30 mins after waking up)
Cortisol (60 mins after waking up)
Cortisol (midday)
Cortisol (afternoon or evening)
Cortisol (evening or night)
Cortisol Awakening Response (CAR) rise response
CAR decline response
DHEAS (at 30 mins after waking up)
CAR cortisol to DHEAS ratio
II. From DRIED URINE sample:
Key Steroid Hormone Summary:
Estradiol (E2)
Progesterone (serum equivalent)
Testosterone
Adrenal Function - Free Cortisol:
Cortisol (morning)
Cortisol (midday)
Cortisol (afternoon/evening)
Cortisol (evening/night)
Adrenal Function - Key Markers:
Total cortisol
Tetrahydrocortisol (THF)
DHEA production (DHEA + Androst + Etioch)
Metabolised Cortisol (THF + THE)
Primary Estrogens
Estradiol (E2)
Estrone (E1)
Estriol (E3)
Estrogen Quotient - E3/(E1+E2)
Estrogen Metabolism - Phase 1
2-OH Estradiol
2-OH Estrone
4-OH Estradiol
4-OH Estrone
16-OH Estrone
2-OH(E1+E2)/16-OHE1
Estrogen Metabolism - Phase 2
2-MeOH Estradiol
2-MeOH Estrone
4-MeOH Estradiol
4-MeOH Estrone
2-MeOH E1/2-OH E1
4-MeOH E2/4-OH E2
4-MeOH E1/4-OH E1
Endocrine Disruptors
Bisphenol A (BPA)
Polyfluoroalkyl Substances (PFAS)
Perfluorooctanoic Acid (PFOA)
Perfluorooctane Sulphonic Acid (PFOS)
Aluminium
Arsenic
Cadmium
Chromium
Lead
Mercury
Nickel
Progesterone Metabolism
Pregnanediol
Allopregnanolone
Allopregnanediol
3a-Dihydroprogesterone
20a-Dihydroprogesterone
Deoxycorticosterone
Corticosterone
Pregnanediol/Estradiol ratio
Primary Androgens
DHEA
DHEAS
Androstenedione
Androsterone
Etiocholanolone
Testosterone
Epi-Testosterone
Dihydroxytestosterone (DHT)
5a-Androstanediol
Key Androgen Ratios
DHEA production (DHEA + Androst + Etioch)
5a-Reductase Activity (Androst/Etioch)
Testosterone/Epi-Testosterone
Nutritional Organic Acids
Xanthurenic Acid
b-Hydroxyisovaleric Acid
Methylmalonic Acid
Homovanillic Acid (HVA)
Vanillylmandelic Acid (VMA)
Kynurenic Acid
Quinolinic Acid
Other Organic Acids
8-OH-deoxyguanosine
Pyroglutamic Acid
Indoleacetic Acid
Urine Creatinines
Creatinine (Pooled Urine)
Creatinine (Morning Urine)
Creatinine (Midday Urine)
Creatinine (Afternoon or Evening Urine)
Creatinine (Evening or Night Urine)
Urinary Glucocorticoids
Total Cortisol
Total Cortisone
Total Cortisol/Cortisone ratio
Tetrahydrocortisol (THF)
Tetrahydrocortisone (THE)
Metabolised Cortisol (THF + THE)
11b-HSD-Index (THF/THE)
Free Cortisols
Cortisol (Morning)
Cortisol (Midday)
Cortisol (Afternoon or Evening)
Cortisol (Evening or Night)
Free Cortisone
Cortisone (Morning)
Cortisone (Midday)
Cortisone (Afternoon or Evening)
Cortisone (Evening or Night)
Urinary Melatonins
Melatonin (Morning)
Melatonin (Midday)
Melatonin (Afternoon or Evening)
Melatonin (Evening or Night)
Change in the normal cortisol circadian rhythm can be caused by many issues including chronic stress, adrenal fatigue, burnout, or problems with the adrenal glands. Chronically high levels are especially bad as they may result in increased appetite and weight gain. Excessive levels cause muscle loss, immune suppression, water retention, and bloating. Low levels are also bad since deficiency can result in fatigue, sluggishness, and low energy.
Using a diurnal cortisol test to check your cortisol levels can help identify potential problems with the adrenal glands. Very high levels are indication of Cushing syndrome and unusually low levels indicate Addison's disease. Therefore, diurnal cortisol test assessing the circadian rhythm profile is crucial to diagnose issues related to the HPA (hypothalamus, pituitary gland, and adrenal glands) hormone balance.
The saliva test is performed using Automated Chemistry/Immunochemistry and Liquid Chromatography-Mass Spectrometry (LC-MS/MS/MS).
The dried urine testing methodologies include Liquid Chromatography-Mass Spectrometry (LC-MS/MS/MS) and Inductively Coupled Mass Spectrometry (ICP-MS).
These are highly complex, very sophisticated, state-of-the-art techniques that are widely used in laboratory testing.
The lab's automated systems also reduce the risks of human-induced errors.
The ICP-MS is the gold standard for heavy metals and toxicity testing with extremely high sensitivity to give your more precise results tailored to your symptoms.
A: Except New York our tests are available in all 49 states. State regulations in NY do not allow us to ship the tests to their residents and many labs often don't have the authority to perform them.
A: The kit contains six saliva tubes and four urine strips for sample collection. Instructions on how to collect the samples, and a form requesting basic information including date and time of collection. The directions are straightforward and easy to follow.
A: In most cases USPS delivers the kit within 3-5 business days. A prepaid return envelope in included for all orders within US. After you ship the sample and it is received by our lab, you get the results within 10-15 business days. This test takes a little longer due to such a large number of markers.
A: The report with your test results will be easy to understand and will have all the necessary details. It will mark your cortisol levels on a healthy range for the time of the day and will specify what are the expected low and high ranges. It will briefly discuss what your numbers mean and next steps you should take to maintain healthy levels.
A: You can use HSA (or FSA/MSA/HRA) accounts to pay for the tests since these are prescription tests (for further confirmation, please check the IRS publication#969). However, please ensure you are not going outside your specified max and min deductible limits. We do not have the capability to process the insurance claim. Since insurance plans vary for individuals we can not guarantee your HSA payment will always be processed by your plan. We suggest talking to your insurance provider if you have any questions.
A: Measuring cortisol levels using saliva is a well researched and thoroughly documented procedure. If fact, it is reliably accurate and one of the best way to testing cortisol levels.
Measurement of other hormones, organic acids and other markers using dried urine test is a relatively new technology.
The variations in results are mainly from two sources: the way samples are collected and the variation from lab-to-lab. Levels are highest in the morning, when we are most energetic, and then drop during the day.
To minimize this variation, you should collect the sample within 30-45 minutes of waking up, without eating, brushing or putting anything else in your mouth that might contaminate the sample.
To minimize the variation from labs, we have partnered with CLIA-certified labs that are regulated by the states, as well as Centers for Medicare and Medicaid Services (CMS). Majority of the tests from these labs are FDA approved to ensure they meet the proper regulatory requirements. Additionally, the College of American Pathologists (CAP) requires inter-laboratory tests to ensure the ranges established by each lab do not drift or are not out of acceptable ranges. This is done by regularly testing reference samples between different labs. Finally, the labs test thousands of samples for different age groups and health conditions, and have well established reference data to compare your results against this large pool.
A: Unfortunately, no. As a lab test provider we can only test and report out data from your sample. We are not authorized to provide any medical recommendations. But we strongly encourage you to discuss the results with your doctor for next steps.
The Endosight+ dried urine and saliva test is one of most comprehensive test to help understand a wide range of symptoms.
Our dried urine test provides results accurate results similar to some of the other tests in the industry, e.g., a Dutch® test, but at a much lower price.
With one Endosight+ test kit, you are able to get insights into your endocrine function, metabolic resilience, endocrine disruptors, organic acids, cortisol awakening response (CAR) and circadian rhythm.
Your detailed report provides comments and summary tailored to your results.
Better health results in better quality of life, and an at home Endosight+ test from RxHomeTest.com not only offers insight into various health related symptoms, but it can also serve as a motivation to treat each of these symptoms and have a better quality of life!
No lab visits or doctor appointments
Saliva test of cortisol (no blood needed)
World class CLIA-certified labs
Physician reviewed results
Fast, secure, and confidential reports
Free shipping
Qualifies for payment using HSA/FSA
Still wondering how to test hormones and organic acids at home?
Each at home dry urine and saliva test kit from RxHomeTest.com includes a prescription and detailed review of the results by one of our physicians at no extra cost. And USPS First Class FREE shipping is included.
RxHomeTest.com processes your sample at the same CLIA-certified labs that thousands of doctors regularly use.
RxHomeTest.com offers convenient, confidential, and reliable results at one of the lowest prices. And we offer a wide range of at-home tests for saliva, urine, stool, buccal swab, and finger prick samples.
You can order at home saliva and dried urine test kit online, without requiring a doctor’s visit or prescription, thus saving time and money. You do not need to take any time off for lab visits which makes the the test very affordable.
Our dried urine test kit offers excellent quality compared to others in the industry (e.g., a Dutch® test) but at a much better price.
